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作者

Qianqian Xie, Ziwei Chen, Jiafeng Wang, Huisi Zhang, Yan Wang, Xiaoyu Wang, Chunyan Li, Yongxiang Wang, Lin Cong, Daniel Ferreira, Anna-Karin Welmer, Lin Song, Yifeng Du, Chengxuan Qiu

作者单位

com. ¹⁵ Shandong Provincial Clinical Research Center for Neurological Diseases, Jinan, Shandong, P.R. China. duyifeng2013@16 Affiliations ¹ Department of Neurology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, P.R. China. ² Department of Neurology, Shandong Provincial Hospital, Shandong University, Jinan, Shandong, P.R. China. ³ Shandong Provincial Clinical Research Center for Neurological Diseases, Jinan, Shandong, P.R. China. ⁴ Institute of Brain Science and Brain-Inspired Research, Shandong First Medical University, Shandong Academy of Medical Sciences, Jinan, Shandong, P.R. China. ⁵ Aging Research Center, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet-Stockholm University, Stockholm, Sweden. ⁶ Division of Clinical Geriatrics, Center for Alzheimer Research, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden. ⁷ Facultad de Ciencias de la Salud, Universidad Fernando Pessoa Canarias, Las Palmas, Spain. ⁸ Division of Physiotherapy, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden. ⁹ Medical Unit Medical Psychology, Women´s Health and Allied Health Professionals Theme, Karolinska University Hospital, Stockholm, Sweden. ¹⁰ Department of Neurology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, P.R. China. zzusonglin@16 com. ¹⁴ Department of Neurology, Shandong Provincial Hospital, Shandong University, Jinan, Shandong, P.R. China. duyifeng2013@16 com. ¹² Shandong Provincial Clinical Research Center for Neurological Diseases, Jinan, Shandong, P.R. China. zzusonglin@16 com. ¹³ Department of Neurology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, P.R. China. duyifeng2013@16 com. ¹⁶ Institute of Brain Science and Brain-Inspired Research, Shandong First Medical University, Shandong Academy of Medical Sciences, Jinan, Shandong, P.R. China. duyifeng2013@16 com. ¹¹ Department of Neurology, Shandong Provincial Hospital, Shandong University, Jinan, Shandong, P.R. China. zzusonglin@16 com.

刊名

Fluids and barriers of the CNS

年份

2025

卷号

Vol.22 No.1

页码

33

ISSN

2045-8118

关键词

Choroid plexus Lateral ventricle Physical function Population-based study White matter hyperintensity.

摘要

Background: The choroid plexus plays an important role in producing cerebrospinal fluid and physical dysfunction has been associated with alterations in CSF circulation. However, no population-based studies have thus far examined the association of ChP with physical function in older people. Methods: This population-based cross-sectional study included 1217 participants in the MRI substudy of the Multimodal Interventions to delay Dementia and disability in rural China. ChP volume was automati...更多

Background: The choroid plexus plays an important role in producing cerebrospinal fluid and physical dysfunction has been associated with alterations in CSF circulation. However, no population-based studies have thus far examined the association of ChP with physical function in older people. Methods: This population-based cross-sectional study included 1217 participants in the MRI substudy of the Multimodal Interventions to delay Dementia and disability in rural China. ChP volume was automatically segmented using three-dimensional T1-weighted sequences. Physical function was assessed using the Short Physical Performance Battery . Data were analyzed using general linear regression and mediation models. Results: Controlling for demographic characteristics, cardiovascular risk factors, stroke, disproportionately enlarged subarachnoid-space hydrocephalus , and total intracranial volume, per 1-ml increase in ChP volume was associated with β-coefficient of -0.24 for SPPB summary score, with the association being stronger in females than in males . The associations were similar across three domains of balance, chair stand, and walking speed. In addition, enlarged ChP volume was associated with increased ventricular volume and white matter hyperintensity volume. Mediation analysis suggested that lateral ventricular volume and periventricular WMH volume significantly mediated the association of ChP volume with the SPPB summary score, with the proportion of mediation being 54.22% and 14.48%, respectively. Conclusion: Larger ChP volume is associated with poorer physical function in older adults, especially in women. The association is largely mediated by lateral ventricular and periventricular WMH volumes.收起

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