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作者

Huimin Yan MD Bowen Li Xuening Zhang MD Zifeng Zuo MD Qinhao Cui MD Yonghao Gai MD, PhD

作者单位

⁴Ultrasound Medicine Department, Linyi people's hospital, Linyi, Shandong, 276000, China ²Ultrasound Medicine Department, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, 250021, China ¹Shandong First Medical University (Shandong Academy of Medical Sciences), Jinan Shandong 250117, China ⁵These authors contributed equally to this work. ³Department of Radiology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, 250021, China

刊名

Clinical Radiology

年份

2025

页码

107105

ISSN

0009-9260

摘要

Purpose To determine the accuracy of two-dimensional shear wave elastography combined with portal hemodynamics in the non-invasive assessment of the extent of liver fibrosis in patients with autoimmune liver disease , using liver biopsy as the reference standard. Methods This study included patients diagnosed with AILD via liver biopsy at a tertiary hospital. We retrospectively collected clinical baseline data, including portal vein flow velocity and diameter measured by abdominal ultrasound, a...更多

Purpose To determine the accuracy of two-dimensional shear wave elastography combined with portal hemodynamics in the non-invasive assessment of the extent of liver fibrosis in patients with autoimmune liver disease , using liver biopsy as the reference standard. Methods This study included patients diagnosed with AILD via liver biopsy at a tertiary hospital. We retrospectively collected clinical baseline data, including portal vein flow velocity and diameter measured by abdominal ultrasound, as well as liver stiffness values measured by 2D-SWE. Univariate logistic regression and stepwise regression methods were used to screen for relevant variables. Receiver operating characteristic curves were constructed for the liver stiffness measurement model and the LSM plus portal flow velocity model, and the areas under the ROC curve of the two models were compared. Result A total of 164 patients with AILD were included in the study. 2D-SWE combined with portal hemodynamic modelling predicted the areas under the curve to be 0.90, 0.92, and 0.94 for significant fibrosis, severe fibrosis, and cirrhosis, respectively. The area under the ROC curve for the 2D-SWE model in predicting significant fibrosis, severe fibrosis, and cirrhosis was 0.85, 0.87, and 0.88, respectively. The difference in AUC between the LSM model and the LSM+PFV model in predicting significant fibrosis, severe fibrosis, and cirrhosis in AILD patients was statistically significant . Conclusion The model of 2D-SWE combined with portal hemodynamics showed good performance in assessing the stage of liver fibrosis in patients with AILD.收起

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