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作者

Longfei Zhu Liyuan Jing Kaiyue Liu Chengxiang Li Shujing Wang Li Xie Shenguang Ge Jinghua Yu

作者单位

¹Institute for Advanced Interdisciplinary Research (iAIR), School of Chemistry and Chemical Engineering, University of Jinan, Jinan 250022, PR China ³Shandong Provincial Key Laboratory of Radiation Oncology, Cancer Research Center, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, Shandong 250117, China ²These authors contributed equally to this work

刊名

Microchemical Journal

年份

2025

卷号

Vol.218

页码

115651

ISSN

0026-265X

摘要

The ability to switch photocurrent polarity from anodic to cathodic modes plays a vital role in minimizing false-positive signals and enhancing detection accuracy in photoelectrochemical biosensing. A novel PEC biosensor employing a 2D/1D ZnInS/InO heterostructure was fabricated, which leveraged polydopamine -mediated photocurrent polarity reversal for ultrasensitive microRNA-622 detection. The Z-scheme ZIS/InO heterojunction exhibited strong redox activity, facilitating efficient separation a...更多

The ability to switch photocurrent polarity from anodic to cathodic modes plays a vital role in minimizing false-positive signals and enhancing detection accuracy in photoelectrochemical biosensing. A novel PEC biosensor employing a 2D/1D ZnInS/InO heterostructure was fabricated, which leveraged polydopamine -mediated photocurrent polarity reversal for ultrasensitive microRNA-622 detection. The Z-scheme ZIS/InO heterojunction exhibited strong redox activity, facilitating efficient separation and transmission of photogenerated charge carriers . This property enhanced the consumption of electron donors, thereby increasing the initial photocurrent response. Furthermore, PDA, characterized by significant spatial potential resistance, was innovatively incorporated to achieve photocurrent polarity switching. PDA not only competes with the substrate for light absorption but also acts as a barrier to block electron donor interaction with the electrode surface, leading to further suppression of the photocurrent signal. Using this heterostructure, we constructed a PEC biosensor by integrating dual signal amplification strategies based on APE1 and DNA walker. The developed miRNA-622 detection method could improve the detection limit of miRNA-622 to 0.6 pM, demonstrating its potential.收起

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