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作者

Shuxin Ma Guangyu Li Yingying Qin

作者单位

Center for Reproductive Medicine，Cheeloo College of Medicine，Shandong University，Jinan，Shandong 250012，China；Key Laboratory of Reproductive Endocrinology，Ministry of Education，Shandong University，Jinan，Shandong 250012，China；Shandong Key Laboratory of Reproductive Medicine，Jinan，Shandong 250012，China；Shandong Provincial Clinical Research Center for Reproductive Health，Jinan，Shandong 250012，China；Shandong Technology Innovation Center for Reproductive Health，Jinan，Shandong 250012，China；National Research Center for Assisted Reproductive Technology and Reproductive Genetics，Shandong University，Jinan，Shandong 250012，China；Center for Reproductive Medicine，Cheeloo College of Medicine，Shandong University，Jinan，Shandong 250012，China；Key Laboratory of Reproductive Endocrinology，Ministry of Education，Shandong University，Jinan，Shandong 250012，China；Shandong Key Laboratory of Reproductive Medicine，Jinan，Shandong 250012，China；Shandong Provincial Clinical Research Center for Reproductive Health，Jinan，Shandong 250012，China；Shandong Technology Innovation Center for Reproductive Health，Jinan，Shandong 250012，China；National Research Center for Assisted Reproductive Technology and Reproductive Genetics，Shandong University，Jinan，Shandong 250012，China；Key Laboratory of Reproductive Endocrinology，Ministry of Education，Shandong University，Jinan，Shandong 250012，China；Shandong Provincial Clinical Research Center for Reproductive Health，Jinan，Shandong 250012，China；Shandong Technology Innovation Center for Reproductive Health，Jinan，Shandong 250012，China；National Research Center for Assisted Reproductive Technology and Reproductive Genetics，Shandong University，Jinan，Shandong 250012，China；State Key Laboratory of Reproductive Medicine and Offspring Health，Center for Reproductive Medicine，Institute of Women，Children and Reproductive Health，Shandong University，Jinan，Shandong 250012，China；Shandong Key Laboratory of Reproductive Medicine，Shandong Provincial Hospital Affiliated to Shandong First Medical University，Jinan，Shandong 250012，China；Research Unit of Gametogenesis and Health of ART-Offspring，Chinese Academy of Medical Sciences (No. 2021RU001)，Jinan，Shandong 250012，China

刊名

中华医学杂志(英文版)

年份

2025

卷号

第138卷

期号

第23期

页码

3069-3082

ISSN

0366-6999

关键词

Ovarian aging Mitochondrial dysfunction Traditional Chinese Medicine Stem cell transplantation Mitochondrial replacement treatment

摘要

Mitochondria serve as multifunctional powerhouses within cells, coordinating essential biological activities that are critical for cell viability, including material metabolism, signal transduction, and the maintenance of homeostasis. They support cells in adapting to complex and fluctuating environments. Oocytes, being the largest cells in multicellular organisms, contain a high number of mitochondria with unique structural characteristics. Mitochondria play active roles in the development and ...更多

Mitochondria serve as multifunctional powerhouses within cells, coordinating essential biological activities that are critical for cell viability, including material metabolism, signal transduction, and the maintenance of homeostasis. They support cells in adapting to complex and fluctuating environments. Oocytes, being the largest cells in multicellular organisms, contain a high number of mitochondria with unique structural characteristics. Mitochondria play active roles in the development and maturation of oocytes. A decline in mitochondrial function negatively affects both the quality and quantity of oocytes, thereby contributing to ovarian aging. However, the specific mechanisms through which mitochondrial dysfunction influences the progression of ovarian aging and impacts reproductive longevity remain unclear. Furthermore, medical strategies aimed at rejuvenating mitochondria to restore ovarian reserve and improve female reproductive potential may open new avenues for clinical treatment. In this review, we summarize the current understanding and key evidence regarding the role of mitochondrial dysfunction in ovarian aging and present emerging medical approaches targeting mitochondria to alleviate premature ovarian aging and enhance reproductive performance.收起

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