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作者单位

² 医学科技创新中心骨科实验室, 山东第一医科大学 ( 山东省医学科学院 ), 山东省济南市 25011 ¹ 山东第一医科大学附属省立医院骨关节科, 山东省济南市 25002

刊名

Chinese Journal of Tissue Engineering Research / Zhongguo Zuzhi Gongcheng Yanjiu

年份

2025

卷号

Vol.29 No.6

页码

1285-1295

ISSN

2095-4344

关键词

bone disease endoplasmic reticulum stress intervertebral disc degeneration osteoarthritis osteoporosis unfolded protein response 内质网应激 未折叠蛋白反应 椎间盘退变 骨关节炎 骨质疏松症 骨骼疾病

摘要

BACKGROUND: The specific molecular mechanisms underlying common degenerative bone diseases, such as osteoarthritis, osteoporosis, and intervertebral disc degeneration, are currently unclear and may involve endoplasmic reticulum stress. At present, research on the systematic role of endoplasmic reticulum stress in the pathogenesis of these common skeletal diseases and related therapeutic progress is relatively limited. OBJECTIVE: To review the role of endoplasmic reticulum stress in common degene...更多

BACKGROUND: The specific molecular mechanisms underlying common degenerative bone diseases, such as osteoarthritis, osteoporosis, and intervertebral disc degeneration, are currently unclear and may involve endoplasmic reticulum stress. At present, research on the systematic role of endoplasmic reticulum stress in the pathogenesis of these common skeletal diseases and related therapeutic progress is relatively limited. OBJECTIVE: To review the role of endoplasmic reticulum stress in common degenerative bone diseases, explore the molecular mechanisms of these diseases in depth, and provide new ideas and perspectives for prevention and treatment of these diseases. METHODS: Relevant literature from 2000 to 2024 was searched in CNKI, WanFang, VIP, PubMed and Web of Science databases using the search terms of “endoplasmic reticulum stress, bone disease, unfolded protein response, osteoarthritis, osteoporosis, intervertebral disc degeneration, autophagy, apoptosis, ferroptosis, pyroptosis” in Chinese and English. After removal of duplicates and older literature, a total of 115 articles met the inclusion criteria. RESULTS AND CONCLUSION: Endoplasmic reticulum stress has a dual effect in regulating cell physiology. Mild endoplasmic reticulum stress promotes osteogenic differentiation and extracellular matrix synthesis; however, persistent excessive endoplasmic reticulum stress leads to cell death. Endoplasmic reticulum stress-induced cell autophagy and apoptosis are closely related to osteoarthritis, osteoporosis, and intervertebral disc degeneration. Aging, drug side effects, metabolic disorders, calcium imbalance, poor lifestyle habits and other reasons may lead to long-term activation of endoplasmic reticulum stress, which causes bone remodeling disorders, cartilage damage, nucleus pulposus cell death and other pathological manifestations, ultimately leading to the occurrence of osteoarthritis, osteoporosis and intervertebral disc degeneration. Intervention in the relevant mechanisms triggering endoplasmic reticulum stress is expected to play a role in the prevention and treatment of common degenerative bone diseases, such as osteoarthritis, osteoporosis and intervertebral disc degeneration.收起

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