获取途径

作者

Lv, Q. Zhang, H. Tian, L. Zhang, R. Zhang, Z. Li, J. Tong, Y. Fan, H. Carr, M.J. Shi, W.

作者单位

The 88 Hospital of The Chinese People's Liberation Army, Taian, Shandong 271000, China Global Station for Zoonosis Control, Global Institution for Collaborative Research and Education (GI-CoRE), Hokkaido University, Sapporo, 001-0020, Japan f National Virus Reference Laboratory, University College Dublin, Belfield, Ireland The Affiliated Hospital of Taishan Medical University, Taian, Shandong 271000, China Beijing Institute of Microbiology and Epidemiology, Beijing, 100071, China a Institute of Pathogen Biology, Taishan Medical College, Taian, Shandong 271000, China

刊名

Ticks and Tick-borne Diseases

年份

2017

卷号

Vol.8 No.3

页码

385-390

ISSN

1877-959X;1877-9603

关键词

Phylogeny Reassortment Recombination Severe fever with thrombocytopenia syndrome virus

摘要

Severe fever with thrombocytopenia syndrome virus has been continuously circulating in Eastern Asia in recent years, without the availability of effective vaccines or antiviral drugs, posing a serious threat to public health, particularly in the central-eastern provinces of China. In this study, we isolated and sequenced four new SFTSV strains from Shandong Province identified in 2015. Phylogenetic analysis, with all publicly available L, M and S gene segments, revealed that the four newly desc...更多

Severe fever with thrombocytopenia syndrome virus has been continuously circulating in Eastern Asia in recent years, without the availability of effective vaccines or antiviral drugs, posing a serious threat to public health, particularly in the central-eastern provinces of China. In this study, we isolated and sequenced four new SFTSV strains from Shandong Province identified in 2015. Phylogenetic analysis, with all publicly available L, M and S gene segments, revealed that the four newly described SFTSV strains belonged to genotype C3. In addition, our phylogenetic analyses also identified two potentially novel sub-lineages of SFTSV, tentatively named C6 and J4. Our comprehensive analysis revealed twenty recombination events in fourteen SFTSV genomes and recombination events were found in the S gene segment for the first time. A total of twenty-six strains were probable SFTSV reassortants, including sixteen which were previously unidentified. We further characterised the genetic constellation of these putative reassortants and classified them into twelve different reassortment forms. Our study revealed multiple evolutionary forces acting on SFTSV, responsible for the increasing genetic diversity of this agent, which could potentially alter the antigenicity and pathogenicity of the virus. This calls for an urgent need for intensified surveillance and the development of vaccines and antiviral drugs against this high-consequence pathogen.收起

文献类型

期刊

浏览量

12