Linezolid-induced thrombocytopenia

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作者单位: Department of Pharmacy, Affiliated Hospital of Taishan Medical College, Taian 271000, China Department of Infectious Diseases, Affiliated Hospital of Taishan Medical College, Taian 271000, China

摘要: Linezolid, one of the oxazolidinone antibiotics, is mainly used to cure serious infection caused by Gram-positive cocci. Its serious adverse reactions mainly involve the blood system, such as thrombocytopenia, anemia, leukocytopenia and so on. In this paper, we reviewed the mechanism of thrombocytopenia caused by linezolid, which is related to myelosuppression or immune mediation. Renal failure, hypohepatia, advanced age, and large doses of long-term treatment are main high-risk factors causing ...更多; Linezolid, one of the oxazolidinone antibiotics, is mainly used to cure serious infection caused by Gram-positive cocci. Its serious adverse reactions mainly involve the blood system, such as thrombocytopenia, anemia, leukocytopenia and so on. In this paper, we reviewed the mechanism of thrombocytopenia caused by linezolid, which is related to myelosuppression or immune mediation. Renal failure, hypohepatia, advanced age, and large doses of long-term treatment are main high-risk factors causing thrombocytopenia.We also introduced the protective measures to provide a reference for reasonable use of linezolid clinically.收起

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