[ Interaction between the single-nucleotide polymorphism of DNA repair gene hOGG1 and HBV infection and its susceptibility to hepatocellular carcinoma].
School of Public Health, Taishan Medical College, Tai' an 271000, China. lji@tsmc.edu.cn
刊名
Wei Sheng Yan Jiu
年份
2011
卷号
Vol.40 No.6
ISSN
1000-8020
分类号
613.7
摘要
OBJECTIVE: To explore the relationship between the single-nucleotide polymorphism of DNA repair gene hOGG1 and the susceptibility to hepatocellular carcinoma , and the interaction between hOGG1 and environmental risk factors in a hepatocarcinoma high risk area. METHOD: This hospital-based case control study was conducted in 500 HCC patients and 507 controls. The polymorphism of hOGG1-Ser326Cys was genotyped by a real time polymerase chain reaction-TaqMan MGB. RESULTS: The allele mutation frequen...更多
OBJECTIVE: To explore the relationship between the single-nucleotide polymorphism of DNA repair gene hOGG1 and the susceptibility to hepatocellular carcinoma , and the interaction between hOGG1 and environmental risk factors in a hepatocarcinoma high risk area. METHOD: This hospital-based case control study was conducted in 500 HCC patients and 507 controls. The polymorphism of hOGG1-Ser326Cys was genotyped by a real time polymerase chain reaction-TaqMan MGB. RESULTS: The allele mutation frequencies of hOGG1-326Cys in the case group and control group were 24.60% and 10.75% respectively . The genotype frequencies of hOGG1 Ser/Ser, Ser/Cys, Cys/Cys were 71.40%, 8.00% and 20.6% in the case group, and were 84.22%, 10.06% and 5.72% in the control group respectively . Compared with the wild hOGG1-326Ser/Ser genotype, the mutant hOGG1 allele increased the risk of HCC . The hOGG1-326Cys allele was the major determinant factor for the risk of HCC. The interaction of hOGG1-326Cys allele with chronic HBV infection tremendously increased the risk of HCC. The synergy index of multiplicative interaction is 0.61 and the synergy index of additive interaction is 1.31. CONCLUSION: The hOGG1-326Cys allele may contribute to the risk of HCC. The synergistic interaction between hOGG1-326Cys allele and chronic HBV infection might modify the risk of HCC. Further studies with larger sample size are warranted to confirm these findings.收起
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