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作者单位

¹山东第一医科大学 (山东省医学科学院) 公共卫生与健康管理学院, 250000 济南. ²山东第一医科大学 (山东 省医学科学院) 临床与基础医学院, 250000 济南. ³山东第一医科大学第二附属医院感染性疾病科, 271000 泰安. ⁴济南市中心医院公共卫生科, 250000 济南.

刊名

Chinese Journal of Oncology Prevention & Treatment

年份

2024

卷号

Vol.16 No.1

页码

84-89

ISSN

1674-5671

关键词

Expression Hepatocellular carcinoma HLA‐DRA protein Immunohistochemistry Prognosis 免疫组织化学 肝细胞癌 表达 预后 Expression Hepatocellular carcinoma HLA‐DRA protein HLA‐DRA蛋白 Immunohistochemistry Prognosis

摘要

Objective To investigate the expression of human leukocyte antigen‐DRA in hepatocellular carcinoma and its relationship with clinicopathological characteristics and prognosis. Methods A total of 273 pairs of HCC tissues and corresponding paracancerous tissues were retrospectively analyzed. The expression of HLA‐DRA protein were detected by immunohisto‐chemistry method, and the clinicopathological characteristics of patients with different HLA ‐ DRA protein expression levels were compared. The ...更多

Objective To investigate the expression of human leukocyte antigen‐DRA in hepatocellular carcinoma and its relationship with clinicopathological characteristics and prognosis. Methods A total of 273 pairs of HCC tissues and corresponding paracancerous tissues were retrospectively analyzed. The expression of HLA‐DRA protein were detected by immunohisto‐chemistry method, and the clinicopathological characteristics of patients with different HLA ‐ DRA protein expression levels were compared. The overall survival and recurrence‐free survival of patients with different HLA‐DRA expression levels were compared by Kaplan‐Meier method. Cox proportional hazards regression was used to assess the factors affecting OS and RFS of HCC patients after hepatectomy. Results The high expression rate of HLA ‐ DRA protein in HCC tissues was lower than that in paracancerous tissues . The OS rate and RFS rate of HCC patients with high HLA‐DRA expression were higher than those with low HLA‐DRA expression. High expression of HLA ‐DRA protein was an independent protective factor for postoperative OS and RFS in HCC patients. Conclusions The high expression rate of HLA‐DRA protein in HCC tissues is lower than that in paracancerous tissues, and its high expression is an independent protective factor for prognosis of HCC patients.收起

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