The variable codons of H5N1 avian influenza A virus haemagglutinin genes.

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作者: By:Shi, WF [ 1 ] Gibbs, MJ [ 2 ] Zhang, YZ [ 3 ] Zhuang, DM [ 4 ] Dun, AS [ 4 ] Yu, GF [ 4 ] Yang, NN [ 1 ] Murphy, RW [ 5 ] Zhu, CD [ 3 ] Hide ResearcherID and ORCID View ResearcherID and ORCID Author ResearcherID ORCID Number ZHU, Chao-Dong E-5961-2011 http://orcid.org/0000-0002-9347-3178 Murphy, Robert http://orcid.org/0000-0001-8555-2338

作者单位: Taishan Med Coll, Inst Life Sci, Tai An 271000, Shandong, Peoples R China Organization-Enhanced Name(s) Taishan Medical University Taishan Med Coll, Dept Basic Med, Tai An 271000, Shandong, Peoples R China Organization-Enhanced Name(s) Taishan Medical University Chinese Acad Sci, Inst Zool, Beijing 100101, Peoples R China Organization-Enhanced Name(s) Institute of Zoology, CAS Chinese Academy of Sciences Royal Ontario Museum, Dept Nat Hist, Toronto, ON M5S 2C6, Canada Organization-Enhanced Name(s) Royal Ontario Museum Australian Natl Univ, Sch Bot & Zool, Fac Sci, Canberra, ACT 0200, Australia Organization-Enhanced Name(s) Australian National University

摘要: We investigated the selection pressures on the haemagglutinin genes of H5N1 avian influenza viruses using fixed effects likelihood models. We found evidence of positive selection in the sequences from isolates from 1997 to 2007, except viruses from 2000. The haemagglutinin sequences of viruses from southeast Asia, Hong Kong and mainland China were the most polymorphic and had similar nonsynonymous profiles. Some sites were positively selected in viruses from most regions and a few of these sites...更多; We investigated the selection pressures on the haemagglutinin genes of H5N1 avian influenza viruses using fixed effects likelihood models. We found evidence of positive selection in the sequences from isolates from 1997 to 2007, except viruses from 2000. The haemagglutinin sequences of viruses from southeast Asia, Hong Kong and mainland China were the most polymorphic and had similar nonsynonymous profiles. Some sites were positively selected in viruses from most regions and a few of these sites displayed different amino acid patterns. Selection appeared to produce different outcomes in viruses from Europe, Africa and Russia and from different host types. One position was found to be positively selected for human isolates only. Although the functions of some positively selected positions are unknown, our analysis provided evidence of different temporal, spatial and host adaptations for H5N1 avian influenza viruses.收起

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