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作者

Tan, XM Li, LY Sun, LY Sun, BD Niu, SB Wang, MH Zhang, XY Sun, WS Zhang, GS Deng, H

作者单位

Peking Union Med Coll, Beijing 100193, Peoples R China Chinese Acad Med Sci, Inst Med Plant Dev, Key Lab Bioact Subst & Resources Utilizat Chinese, Minist Educ, Beijing 100193, Peoples R China Taishan Med Univ, Sch Pharmaceut Sci, Tai An 271016, Shandong, Peoples R China Beijing City Univ, Sch Biol Med, Beijing 450046, Peoples R China Liaoning Res Inst Cash Crops, Liaoyang 111000, Peoples R China Chinese Acad Sci, Inst Microbiol, Beijing 100090, Peoples R China Chinese Acad Agr Sci, Inst Agr Resources & Reg Planning, Key Lab Microbial Resources Collect & Preservat, Minist Agr, Beijing 100081, Peoples R China

刊名

Journal of Antibiotics

年份

2018

ISSN

1881-1469

关键词

Drug screening Medicinal chemistry

摘要

Endophytic fungi from desert, arid, and grassland areas are an ecologically important but unique group with poor chemical investigation. During our ongoing study to mine bioactive secondary metabolites from unique fungal environments, a new shunt product spiciferone F (1) including two new analogs spiciferones G (2) and H (3) together with four known ones spiciferone A (4), spiciferol A (5), 6, and 7 were isolated from endophytic fungus Phoma betae inhabiting in plant Kalidium foliatum (Pall.) M...更多

Endophytic fungi from desert, arid, and grassland areas are an ecologically important but unique group with poor chemical investigation. During our ongoing study to mine bioactive secondary metabolites from unique fungal environments, a new shunt product spiciferone F (1) including two new analogs spiciferones G (2) and H (3) together with four known ones spiciferone A (4), spiciferol A (5), 6, and 7 were isolated from endophytic fungus Phoma betae inhabiting in plant Kalidium foliatum (Pall.) Moq from Ningxia Province of West China. The planar, relative, and absolute configurations of these new compounds were elucidated by nuclear magnetic resonance, high-resolution electrospray ionization mass spectrometry, and electronic circular dichroism experiments. According to the shunt products, intermediates and analogs isolated from this endophytic fungus, the possible biosynthetic pathway of spiciferones was reconstructed. Compounds 1–7 were evaluated cytotoxic activities against three cancer cell lines HCT 116, HeLa, and MCF7, and only did 1 display strong biological effect against MCF7 with a half-maximal inhibitory concentration value at 7.73 ± 0.11 μM compared with the cis-platinum (14.32 ± 1.01 μM).收起

学科

【SCI学科】IMMUNOLOGY;BIOTECHNOLOGY & APPLIED MICROBIOLOGY;MICROBIOLOGY;PHARMACOLOGY & PHARMACY 【ESI学科】PHARMACOLOGY & TOXICOLOGY

影响因子

2016年:2.237;2015年:2.173;2014年:1.73;2013年:2.041;2012年:2.191

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期刊

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