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作者

Bi, Y. Chen, Q. Wang, Q. Chen, J. Jin, T. Wong, G. Quan, C. Liu, J. Wu, J. Yin, R. Zhao, L. Li, M. Ding, Z. Zou, R. Xu, W. Li, H. Wang, H. Tian, K. Fu, G. Huang, Y. Shestopalov, A. Li, S. Xu, B. Yu, H. Luo, T. Lu, L. Xu, X. Luo, Y. Liu, Y. Shi, W. Liu, D. Gao, G.F.

作者单位

g Department of Veterinary Preventive Medicine, College of Veterinary Medicine, Jilin University, Jilin, China p Laboratory of Animal Infectious Diseases, College of Animal Sciences and Veterinary Medicine, Guangxi University, Nanning, China CAS Key Laboratory of Pathogenic Microbiology and Immunology, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Disease, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China t Savaid Medical School, University of Chinese Academy of Sciences, Beijing, China l Research Institute of Experimental and Clinical Medicine, Novosibirsk State University, Novosibirsk, Russian Federation m College of Veterinary Medicine, South China Agricultural University, Guangzhou, China q Institute of Pathogen Biology, Taishan Medical College, Taian, China i Diqing Tibetan Autonomous Prefecture Centers for Disease Control and Prevention, Shangri-la, China r Network Information Center, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China o Division of Infectious Disease, Key Laboratory of Surveillance and Early-Warning on Infectious Disease, Chinese Center for Disease Control and Prevention, Beijing, China Center for Influenza Research and Early-Warning (CASCIRE), Chinese Academy of Sciences, Beijing, China s Broad Institute of Harvard and MIT, Cambridge, MA, United States CAS Key Laboratory of Special Pathogens and Biosafety, Wuhan Institute of Virology, Chinese Academy of Sciences, Hubei, China j National Research Center for Veterinary Medicine, Luoyang, China n Ministry of Education Key Laboratory for Earth System Modelling, Center for Earth System Science, Tsinghua University, Beijing, China a Shenzhen Key Laboratory of Pathogen and Immunity, State Key Discipline of Infectious Disease, Shenzhen Third People\'s Hospital, Shenzhen, China f National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention (China CDC), Beijing, China h Yunnan Center for Disease Control and Prevention, Kunming, China China National Genebank-Shenzhen, BGI-Shenzhen, Shenzhen, China k Institute of Animal Husbandry and Veterinary Medicine, Fujian Academy of Agricultural Sciences, Fuzhou, China

刊名

Cell Host and Microbe

年份

2016

卷号

Vol.20 No.6

页码

810-821

ISSN

1931-3128

关键词

birds evolution genesis H5N6 avian influenza human infection live poultry markets prevalence resassortment

分类号

579

摘要

Constant surveillance of live poultry markets (LPMs) is currently the best way to predict and identify emerging avian influenza viruses (AIVs) that pose a potential threat to public health. Through surveillance of LPMs from 16 provinces and municipalities in China during 2014–2016, we identified 3,174 AIV-positive samples and isolated and sequenced 1,135 AIVs covering 31 subtypes. Our analysis shows that H5N6 has replaced H5N1 as one of the dominant AIV subtypes in southern China, especially in ...更多

Constant surveillance of live poultry markets (LPMs) is currently the best way to predict and identify emerging avian influenza viruses (AIVs) that pose a potential threat to public health. Through surveillance of LPMs from 16 provinces and municipalities in China during 2014–2016, we identified 3,174 AIV-positive samples and isolated and sequenced 1,135 AIVs covering 31 subtypes. Our analysis shows that H5N6 has replaced H5N1 as one of the dominant AIV subtypes in southern China, especially in ducks. Phylogenetic analysis reveals that H5N6 arose from reassortments of H5 and H6N6 viruses, with the hemagglutinin and neuraminidase combinations being strongly lineage specific. H5N6 viruses constitute at least 34 distinct genotypes derived from various evolutionary pathways. Notably, genotype G1.2 virus, with internal genes from the chicken H9N2/H7N9 gene pool, was responsible for at least five human H5N6 infections. Our findings highlight H5N6 AIVs as potential threats to public health and agriculture.收起

学科

【SCI学科】PARASITOLOGY;MICROBIOLOGY;VIROLOGY 【ESI学科】MICROBIOLOGY

影响因子

2018年:15.753;2017年:17.872;2016年:14.946;2015年:12.552;2014年:12.328

文献类型

期刊

浏览量

25