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作者

Jia, Y. Qu, B. Wang, Z. Han, X. Ren, G.

作者单位

Taishan Medical College, Taishan Hospital, Taian, Shandong, China a Internal Medicine, United States Clinical Laboratory, United States Department of Gastroenterology, Taishan Hospital, No. Tianwaicun Street, Taian City, 271000, China

刊名

Medicine (United States)

年份

2018

卷号

Vol.97 No.34

ISSN

0025-7974;1536-5964

关键词

Chronic alcohol consumption Cytokine profiles H. pylori caga antibody positive H. pylori infection Men Oxidative balance

摘要

This study aimed to explore the effects of active and latent Helicobacter pylori infection coupled with alcohol consumption on cytokine profiles and markers of oxidative balance in men seropositive for H. pylori CagA Ab. The 100 male subjects were divided into groups with active H. pylori infection and H. pylori CagA Ab coupled with chronic alcohol ingestion , latent H. pylori infection with H. pylori CagA Ab coupled with chronic alcohol ingestion , and latent H. pylori infection with H. pylori ...更多

This study aimed to explore the effects of active and latent Helicobacter pylori infection coupled with alcohol consumption on cytokine profiles and markers of oxidative balance in men seropositive for H. pylori CagA Ab. The 100 male subjects were divided into groups with active H. pylori infection and H. pylori CagA Ab coupled with chronic alcohol ingestion , latent H. pylori infection with H. pylori CagA Ab coupled with chronic alcohol ingestion , and latent H. pylori infection with H. pylori CagA Ab without chronic alcohol ingestion . No differences in serum levels of CRP, IL-10, ADP, E-selectin, MDA, or SOD were detected between the 3 groups or between any 2 groups . The serum IL-6 and TNF-a concentrations in groups A and B were significantly lower than those in group C . However, there were no differences in serum IL-6 and TNF-a between group A and group B . In conclusion, active or latent H. pylori infection coupled with chronic alcohol ingestion may decrease certain cytokines, that is, IL-6 and TNF-a, in men with H. pylori CagA Ab seropositivity. However, there was no difference in the detected cytokine profile between active and latent H. pylori infection coupled with chronic alcohol ingestion, and no changes were detected in markers of oxidative balance in men with H. pylori CagA Ab.收起

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