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作者

Yipeng Yin Wei Wang Mingbo Tang Wei Liu

作者单位

Department of Thoracic Surgery，The First Hospital of Jilin University，Changchun，China；Key Laboratory of Endocrine Glucose & Lipids Metabolism and Brain Aging，Ministry of Education，Department of Endocrinology，Shandong Provincial Hospital Affiliated to Shandong First Medical University，Jinan，China；Shandong Key Laboratory of Endocrinology and Lipid Metabolism，Jinan，China；Shandong Institute of Endocrine and Metabolic Diseases，Jinan，China；“Chuangxin China” Innovation Base of Stem Cell and Gene Therapy for Endocrine Metabolic Diseases，Jinan，China；Shandong Engineering Laboratory of Prevention and Control for Endocrine and Metabolic Diseases，Jinan，China；Shandong Engineering Research Center of Stem Cell and Gene Therapy for Endocrine and Metabolic Diseases，Jinan，China；Department of Thoracic Surgery，The First Hospital of Jilin University，Changchun，China；Department of Thoracic Surgery，The First Hospital of Jilin University，Changchun，China

刊名

纵隔医学杂志

年份

2024

卷号

第8卷

期号

第1期

页码

AB053

关键词

Tumor size thymoma thymic carcinoma

摘要

Background This study aims to clarify the impact of tumor size on the prognosis of patients diagnosed with thymoma and thymic carcinoma, leveraging data from a population-based registry. Methods Utilizing the Surveillance, Epidemiology, and End Results database, this retrospective analysis identified patients diagnosed with thymoma and thymic carcinoma from 2000 to 2020. Propensity score matching was employed to mitigate potential statistical biases between groups categorized by tumor size . Re...更多

Background This study aims to clarify the impact of tumor size on the prognosis of patients diagnosed with thymoma and thymic carcinoma, leveraging data from a population-based registry. Methods Utilizing the Surveillance, Epidemiology, and End Results database, this retrospective analysis identified patients diagnosed with thymoma and thymic carcinoma from 2000 to 2020. Propensity score matching was employed to mitigate potential statistical biases between groups categorized by tumor size . Results The study included a total of 3,857 patients, comprising 2,688 with thymoma and 1,169 with thymic carcinoma. Multivariate analysis demonstrated that tumors ≤6.5 cm independently correlated with improved cancer-specific survival and overall survival in both thymoma and thymic carcinoma cohorts. Subgroup analysis revealed that smaller tumors conferred survival benefits in patients with Masaoka-Koga stage IIB thymomas and stage III/IV thymic carcinomas . Additionally, World Health Organization type A/AB/B1 and type B2/B3 thymomas with tumors ≤6.5 cm exhibited superior CSS and OS . Conclusions Through propensity matching analysis utilizing the SEER database, this study underscores the prognostic significance of tumor size in both early-stage thymoma and advanced-stage thymic carcinoma, identifying a critical threshold of 6.5 cm. In the WHO classification, tumor size based on the cut-off value of 6.5 cm has a greater impact on the prognosis of type B2/B3 than A/AB/B1 .收起

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