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作者

Fu, Qiang Lin, Yu Zheng, Fei Xu, Yuanji Xue, Wenji Zhang, Ye Wang, Qifeng Yue, Jinbo Yang, Pei Zhang, Wencheng Chen, Junqiang

作者单位

^dDepartment of Radiation Oncology, National Cancer Center, National Clinical Research Center for Cancer / Cancer Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, 100021, China ^fDepartment of Radiation Oncology, Shandong Cancer Hospital and Institute, Shandong First Medical University, Shandong Academy of Medical Sciences, Jinan, 250117, China ^eDepartment of Radiation Oncology, Sichuan Clinical Research Center for Cancer, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, University of Electronic Science and Technology of China, Chengdu, 610041, China ^gDepartment of Radiation Oncology, Hunan Cancer Hospital, The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, 410013, China ^aDepartment of Oncology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China ^cProfessional Committee of Radiation Oncology, Chinese Medicine Education Association (CMEA), Changsha, 410013, China ^bDepartment of Radiation Oncology, Fujian Cancer Hospital, Teaching Hospital of Cancer Clinical Medicine, Fujian Medical University, Fuzhou, 350014, China ^hDepartment of Radiation Oncology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin's Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin, Tianjin, 300060, China

刊名

Chinese Journal of Radiation Oncology

年份

2025

卷号

Vol.34 No.9

页码

874-881

ISSN

1004-4221

关键词

Progress Radiation-induced esophageal injury Radiotherapy

摘要

Radiation-induced esophageal injury is a frequent complication following radiotherapy for thoracic and head-neck malignancies, which may lead to severe sequelae including esophageal stricture and perforation, adversely affecting patients' quality of life and therapeutic outcomes. With advancements in radiotherapy techniques — particularly the adoption of unconventional fractionation regimens, concurrent chemoradiotherapy, and combined molecular targeted / immunotherapy — the incidence of RIEI h...更多

Radiation-induced esophageal injury is a frequent complication following radiotherapy for thoracic and head-neck malignancies, which may lead to severe sequelae including esophageal stricture and perforation, adversely affecting patients' quality of life and therapeutic outcomes. With advancements in radiotherapy techniques — particularly the adoption of unconventional fractionation regimens, concurrent chemoradiotherapy, and combined molecular targeted / immunotherapy — the incidence of RIEI has been increasing. In this review, recent advances in understanding the pathogenesis, clinical manifestations, risk factors, and management strategies for RIEI were comprehensively summarized. Current therapeutic approaches have evolved beyond conventional anti-inflammatory and nutritional support to include novel interventions such as targeted therapy, free radical scavengers, and microbiota modulation, etc. Future research should prioritize the development of optimized, individualized prevention and treatment protocols to mitigate RIEI risk and improve patient prognosis.收起

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