Research progress in osteoradionecrosis of the jaws

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作者: Ge, Yunfan Wu, Yongsheng Zhang, Ye Wang, Qifeng Yang, Pei Zhang, Wencheng Yue, Jinbo

作者单位: ^dDepartment of Radiation Oncology, National Cancer Center, National Clinical Research Center for Cancer / Cancer Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, 100021, China ^eDepartment of Radiation Oncology, Sichuan Clinical Research Center for Cancer, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, University of Electronic Science and Technology of China, Chengdu, 610041, China ^bDepartment of Radiology, Qilu Hospital, Shandong University, Jinan, 250012, China ^cProfessional Committee of Radiation Oncology, Chinese Medicine Education Association (CMEA), Changsha, 410013, China ^gDepartment of Radiation Oncology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin's Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin, Tianjin, 300060, China ^hDepartment of Radiation Oncology, Shandong Cancer Hospital and Institute, Shandong First Medical University, Shandong Academy of Medical Sciences, Jinan, 250117, China ^aSchool of Clinical Medicine, Shandong Second Medical University, Weifang, 261053, China ^fDepartment of Radiation Oncology, Hunan Cancer Hospital, The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, 410013, China

关键词: Head and neck neoplasms Mechanism of injury Radioactive osteonecrosis of the jaws Radiotherapy Review

摘要: Osteoradionecrosis of the jaws is among the most severe oral complications following radiotherapy for head and neck tumors. It is essentially a form of pathological necrosis of the jawbone induced by radiation therapy. ORNJ is defined as bone damage, primarily characterized by inflammation and necrosis, occurring in the jawbone within the irradiated area and accompanied by soft tissue injury, persisting for more than 3 months without spontaneous healing. Diagnosis requires exclusion of other po...更多; Osteoradionecrosis of the jaws is among the most severe oral complications following radiotherapy for head and neck tumors. It is essentially a form of pathological necrosis of the jawbone induced by radiation therapy. ORNJ is defined as bone damage, primarily characterized by inflammation and necrosis, occurring in the jawbone within the irradiated area and accompanied by soft tissue injury, persisting for more than 3 months without spontaneous healing. Diagnosis requires exclusion of other potential etiologies, including primary tumor recurrence, medication-related osteonecrosis, and radiation-induced neoplasms of the jawbone, etc. In this review, recent advances in the epidemiology, risk factors, diagnosis, classification and staging, dosimetric parameters, pathogenesis, treatment, and prevention of radiation-induced osteonecrosis of the jaws were summarized.收起

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