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作者

Yi Li, Feng-Xian Zhang, Wen-Long Zhang, Meng-Jun Shen, Jia-Wei Yi, Qing-Qing Zhao, Qing-Ping Zhao, Li-Yan Hao, Jia-Jia Qi, Wan-Hu Li, Xiao-Dong Wu, Long Zhao, Yin Wang

作者单位

com. ⁶ Department of Nuclear Medicine, Shanghai Pulmonary Hospital, School of Medicine, Tongji University, Shanghai, China. Electronic address: egg1961@aliyun.com. ⁷ Department of Ultrasound, Shanghai Pulmonary Hospital, School of Medicine, Tongji University, Shanghai, China. Electronic address: lpbbl@aliyun.com. Affiliations ¹ Department of Nuclear Medicine, Shanghai Pulmonary Hospital, School of Medicine, Tongji University, Shanghai, China. ² Department of Radiology, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan 250117, Shandong, China. ³ Department of Ultrasound, Shanghai Pulmonary Hospital, School of Medicine, Tongji University, Shanghai, China. ⁴ Department of PET/CT Center, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan 250117, Shandong, China. ⁵ Department of Radiology, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan 250117, Shandong, China. Electronic address: wxd19942012@16

刊名

Lung cancer (Amsterdam, Netherlands)

年份

2026

卷号

Vol.215

页码

109353

ISSN

1872-8332

关键词

(18)F-FDG PET/CT Circulating tumor cells Folate receptor Lung adenocarcinoma Radiomics.

摘要

Introduction: This study aimed to develop and validate a machine learning model that integrates radiomic features from 2-[F]fluoro-2-deoxy-D-glucose positron emission tomography/computed tomography with folate receptor-positive circulating tumor cells for the preoperative prediction of tumor differentiation grade, as defined by the International Association for the Study of Lung Cancer grading system, in patients with clinical stage IA lung adenocarcinoma . Materials and methods: This retros...更多

Introduction: This study aimed to develop and validate a machine learning model that integrates radiomic features from 2-[F]fluoro-2-deoxy-D-glucose positron emission tomography/computed tomography with folate receptor-positive circulating tumor cells for the preoperative prediction of tumor differentiation grade, as defined by the International Association for the Study of Lung Cancer grading system, in patients with clinical stage IA lung adenocarcinoma . Materials and methods: This retrospective study enrolled a total of 1797 patients from two medical centers. Pathological evaluation identified 1008 cases as poorly differentiated tumors and 789 cases as non-poorly differentiated tumors . Three kinds of models were constructed, including the clinical, radiomics, and combined model. The combined model was established using 5 machine learning algorithms. Model performance was assessed by the area under the receiver operating characteristic curve , with Shapley Additive Explanations employed for interpretability. Results: The light gradient boosting machine combined model, incorporating FR-CTCs and 11 radiomic features, demonstrated superior predictive performance compared to other models, with AUCs of 0.960, 0.906, and 0.902 in the training, internal validation, and external validation sets. Additionally, this model exhibited favorable calibration and high net benefit. Progression-free survival was significantly different between the PDT and n-PDT patients, and between the high-risk and low-risk patients stratified by this model . Conclusion: The LightGBM combined model effectively predicts tumor differentiation grade in patients with clinical stage IA lung ADC and can be used as a tool for risk stratification of these patients.收起

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