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作者

Jinpeng Niu, Zihao Zheng, Ziqi Wang, Longchun Xu, Qingmin Meng, Xiaotong Zhang, Liangfeng Kuang, Shigang Wang, Li Dong, Jianfeng Qiu, Qing Jiao, Weifang Cao

作者单位

Affiliations ¹ Department of Radiology, The Second Affiliated Hospital of Shandong First Medical University, Tai'an, China. ² Department of Radiology, Shandong First Medical University and Shandong Academy of Medical Science, Tai'an, China. ³ Ministry of Education (MOE) Key Laboratory for Neuroinformation, School of Life Sciences and Technology, The Clinical Hospital of Chengdu Brain Science Institute, University of Electronic Science and Technology of China, Chengdu, China. ⁴ Department of Interventional Radiology, Taian Central Hospital, Tai'an, China.

刊名

Frontiers in neuroscience

年份

2022

卷号

Vol.16

页码

984571

ISSN

1662-4548

关键词

aging fMRI inter-subject functional correlation movie thalamo-cortical.

摘要

An increasing number of studies have shown that the functional interactions between the thalamus and cerebral cortices play an important role in cognitive function and are influenced by age. Previous studies have revealed age-related changes in the thalamo-cortical system within individuals, while neglecting differences between individuals. Here, we characterized inter-subject functional correlation between the thalamus and several cortical brain networks in 500 healthy participants aged 18-87 ...更多

An increasing number of studies have shown that the functional interactions between the thalamus and cerebral cortices play an important role in cognitive function and are influenced by age. Previous studies have revealed age-related changes in the thalamo-cortical system within individuals, while neglecting differences between individuals. Here, we characterized inter-subject functional correlation between the thalamus and several cortical brain networks in 500 healthy participants aged 18-87 years old from the Cambridge Centre for Aging and Neuroscience cohort using movie-watching state fMRI data. General linear models were performed to assess age-related changes in ISFC of thalamo-cortical networks and the relationship between ISFC and fluid intelligence. We found significant age-related decreases in ISFC between the posterior thalamus and the attentional network, sensorimotor network, and visual network . Meanwhile, the ISFC between the thalamus and higher-order cortical networks, including the default mode network, salience network and control network, showed complex changes with age. Furthermore, the altered ISFC of thalamo-cortical networks was positively correlated with decreased fluid intelligence . Overall, our results provide further evidence that alterations in the functional integrity of the thalamo-cortical system might play an important role in cognitive decline during aging.收起

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