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作者

Chuansong Quan Qinghua Liu Lijuan Yu Chunjing Li Kaixiao Nie Guoyong Ding Hong Zhou Xinli Wang Wenwen Sun Huiliang Wang Maokui Yue Li Wei Wenjun Zheng Qiang Lyu Weijia Xing Zhenjie Zhang Michael J. Carr Hong Zhang Weifeng Shi

作者单位

⁸Department of Critical Care Medicine, The Second Affiliated Hospital of Shandong First Medical University, Taian, 271000, China ⁷Department of Pathology, The Second Affiliated Hospital of Shandong First Medical University, Taian, 271000, China ¹⁰National Virus Reference Laboratory, School of Medicine, University College Dublin, Dublin 4, Ireland ⁹Department of Respiratory Medicine, The Second Affiliated Hospital of Shandong First Medical University, Taian, 271000, China ¹Department of Infectious Disease, The Second Affiliated Hospital of Shandong First Medical University, Taian, 271000, China ¹¹International Collaboration Unit, International Institute for Zoonosis Control, Hokkaido University, N20 W10 Kita-ku, Sapporo, 001-0020, Japan ⁴Department of Clinical Laboratory, The Second Affiliated Hospital of Shandong First Medical University, Taian 271000, China ⁵Department of Hematology, The Second Affiliated Hospital of Shandong First Medical University, Taian, 271000, China ³These authors contributed equally ²Key Laboratory of Etiology and Epidemiology of Emerging Infectious Diseases in Universities of Shandong, Shandong First Medical University & Shandong Academy of Medical Sciences, Taian, 271000, China ¹²Lead contact ⁶School of Public Health, Shandong First Medical University & Shandong Academy of Medical Sciences, Ji’nan, 250117, China

刊名

iScience

年份

2023

页码

106799

ISSN

2589-0042

关键词

Severe fever with thrombocytopenia syndrome SFTS monoclonal plasma cells humoral response bone marrow virus infection

摘要

The impairment of antibody-mediated immunity is a major factor associated with fatal cases of severe fever with thrombocytopenia syndrome . By collating the clinical diagnosis reports of 30 SFTS cases, we discovered the overproliferation of monoclonal plasma cells in bone marrow which has only been reported previously in multiple myeloma. The ratio of CD38cLambda versus CD38cKappa in SFTS cases with MCP cells were significantly higher than that in normal cases. MCP cells presented transient exp...更多

The impairment of antibody-mediated immunity is a major factor associated with fatal cases of severe fever with thrombocytopenia syndrome . By collating the clinical diagnosis reports of 30 SFTS cases, we discovered the overproliferation of monoclonal plasma cells in bone marrow which has only been reported previously in multiple myeloma. The ratio of CD38cLambda versus CD38cKappa in SFTS cases with MCP cells were significantly higher than that in normal cases. MCP cells presented transient expression in the bone marrow, which was distinctly different from multiple myeloma. Moreover, the SFTS patients with MCP cells had higher clinical severity. Further, the overproliferation of MCP cells was also observed in SFTSV-infected mice with lethal infectious doses. Together, SFTSV infection induces transient overproliferation of monoclonal lambda-type plasma cells, which have important implications for the study of SFTSV pathogenesis, prognosis and the rational development of therapeutics.收起

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