Advances in the concomitant chronic liver disease and colorectal cancer liver metastasis

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作者单位: ¹Department of Hepatobiliopancreatic Surgery, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences

关键词: colorectal cancer(crc) liver metastasis chronic liver disease tumor microenvironment (tme)

摘要: Liver metastasis is a key factor contributing to the poor prognosis of patients with colorectal cancer , and chronic liver diseases promote the occurrence and development of CRC liver metastasis through various mechanisms such as altering the tumor microenvironment . This article reviewed the association of chronic liver diseases, such as chronic hepatitis B , non-alcoholic fatty liver disease , alcoholic liver disease , drug-induced liver injury , with CRLM. It briefly reviewed recent epidemio...更多; Liver metastasis is a key factor contributing to the poor prognosis of patients with colorectal cancer , and chronic liver diseases promote the occurrence and development of CRC liver metastasis through various mechanisms such as altering the tumor microenvironment . This article reviewed the association of chronic liver diseases, such as chronic hepatitis B , non-alcoholic fatty liver disease , alcoholic liver disease , drug-induced liver injury , with CRLM. It briefly reviewed recent epidemiological trends of these chronic liver diseases. Furthermore, the relationship between chronic liver diseases and CRLM is elaborated from the aspects of risk factors, pathogenic mechanisms, and management. The mechanisms by which these chronic liver diseases affect CRLM are explored.收起

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