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作者

Jihai, Jin Guangrong, Lin Yujuan, Liu Limei, Fu

作者单位

^cDepartment of Pediatrics, Binzhou People's Hospital Affiliated, Shandong First Medical University, Binzhou, 256610, China ^bDepartment of Thyroid Surgery, Binzhou People's Hospital Affiliated, Shandong First Medical University, Binzhou, 256610, China ^aDepartment of Breast Surgery, Binzhou People's Hospital Affiliated, Shandong First Medical University, Binzhou, 256610, China ^dDepartment of Pathology, Binzhou People's Hospital Affiliated, Shandong First Medical University, Binzhou, 256610, China

刊名

Cancer Research and Clinic

年份

2023

卷号

Vol.35 No.3

页码

179-184

ISSN

1006-9801

关键词

Breast neoplasms Cadherins Carcinoma Epithelial‐mesenchymal transition Fibronectins pregnancy associated Prognosis Tissue inhibitor of matrix metalloproteinase‐1

摘要

Objective To investigate the expressions of tissue inhibitor of matrix metalloproteinase‐1 and fibronectin 1 in pregnancy associated breast cancer and their correlations with expression of E‐cadherin . Methods The clinicopathological data of 55 PABC patients in Binzhou People's Hospital Affiliated to Shandong First Medical University from January 2011 to December 2020 were retrospectively analyzed. Immunohistochemistry was used to detect expressions of TIMP1, FN1 and E‐cad in cancer tissues a...更多

Objective To investigate the expressions of tissue inhibitor of matrix metalloproteinase‐1 and fibronectin 1 in pregnancy associated breast cancer and their correlations with expression of E‐cadherin . Methods The clinicopathological data of 55 PABC patients in Binzhou People's Hospital Affiliated to Shandong First Medical University from January 2011 to December 2020 were retrospectively analyzed. Immunohistochemistry was used to detect expressions of TIMP1, FN1 and E‐cad in cancer tissues and corresponding paracancerous tissues . The expressions of TIMP1 and FN1 proteins in fresh intraoperative frozen cancer tissues and paracancerous tissues of 10 PABC patients were detected by Western blotting. The correlations of TIMP1 and FN1 expressions with clinicopathological characteristics of patients were analyzed by χ test, the correlation of TIMP1 and FN1 expressions with E‐cad expression was analyzed by Spearman method, and the correlation of TIMP1 and FN1 expressions with survival was analyzed by Kaplan‐Meier method. Results The positive rates of TIMP1 and FN1 in PABC tissues were 72.7% and 58.2% , and 25.5% and 18.2% in paracancerous tissues, and the differences were statistically significant ; the median overall survival time of TIMP1‐positive group and FN1‐positive group were 51 months and 43 months , while that of TIMP1‐negative group and FN1‐negative group were 89 months and 87 months . Conclusions TIMP1 and FN1 expressions are elevated in PABC tissues and negatively correlated with E ‐ cad expression, TIMP1 and FN1 may be involved in PABC invasion through epithelial‐mesenchymal transition and affect the prognosis of patients.收起

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