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作者

Xiaoxiao Yuan Xin Yang Zhenran Xu Jie Li ChengJun Sun Ruimin Chen Haiyan Wei Linqi Chen Hongwei Du Guimei Li Yu Yang Xiaojuan Chen Lanwei Cui Junfen Fu Jin Wu Zhihong Chen Xin Fang Zhe Su Miaoying Zhang Jing Wu Xin Chen Jiawei Zhou Yue Luo Lei Zhang Ruirui Wang Feihong Luo

作者单位

¹⁶Department of Neuroendocrinology Pediatrics, Affiliated Hospital of Qingdao University, Qingdao 266003, China ¹¹The Affiliated Children's Hospital of Nanchang University, Nanchang 330006, China ⁵Teaching and Research Division, School of Chinese Medicine, Hong Kong Baptist University, Kowloon Tong, Hong Kong 999077, China ⁷Department of Endocrinology and Inherited Metabolic, Children’s Hospital Affiliated to Zhengzhou University, Zhengzhou 450000, China ⁸Children's Hospital of Soochow University, Suzhou 215000, China ¹⁸Shenzhen Children's Hospital, Shenzhen 518038, China ¹³The First Affiliated Hospital of Harbin Medical University, Harbin 150001, China ¹⁴Department of Endocrinology, Children’s Hospital, Zhejiang University School of Medicine, Hangzhou 310005, China ⁶Fuzhou Children's Hospital of Fujian Medical University, Fuzhou 350000, China ¹⁷Fujian Medical University Union Hospital, Fuzhou 350001, China ¹²Department of Endocrinology, Genetics and Metabolism, The Children’s Hospital of Shanxi Province, Taiyuan 030013, China ¹⁹Guizhou University of Traditional Chinese Medicine, Guizhou 550025, China ¹⁵Department of Pediatrics, West China Second University Hospital, Sichuan University, Chengdu 610041, China ²⁰Lead contact ⁴Section of Endocrinology, Internal Medicine, School of Medicine, Yale University, New Haven, CT 06511, United States ⁹The First Hospital of Jilin University, Jilin 130000, China ³Department of Food Science and Technology, School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai 200240, China ²Shanghai Innovation Center of TCM Health Service, Shanghai University of Traditional Chinese Medicine, Shanghai 200120, China ¹Department of Pediatric Endocrinology and Inherited Metabolic Diseases, Children’s Hospital of Fudan University, Shanghai 201102, China ¹⁰Department of Pediatric Endocrinology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan 250021, China

刊名

iScience

年份

2024

页码

110252

ISSN

2589-0042

关键词

Type 1 diabetes blood microbiome 16S rRNA gene sequencing

摘要

Blood microbiome signatures in patients with type 1 diabetes remain unclear. We profile blood microbiome using 16S rRNA gene sequencing in 77 controls and 64 children with new-onset T1D, and compared it with the gut and oral microbiomes. The blood microbiome of patients with T1D is characterized by increased diversity and perturbed microbial features, with a significant increase in potentially pathogenic bacteria compared with controls. Thirty-six representative genera of blood microbiome were ...更多

Blood microbiome signatures in patients with type 1 diabetes remain unclear. We profile blood microbiome using 16S rRNA gene sequencing in 77 controls and 64 children with new-onset T1D, and compared it with the gut and oral microbiomes. The blood microbiome of patients with T1D is characterized by increased diversity and perturbed microbial features, with a significant increase in potentially pathogenic bacteria compared with controls. Thirty-six representative genera of blood microbiome were identified by random forest analysis, providing strong discriminatory power for T1D with an AUC of 0.82. PICRUSt analysis suggested that bacteria capable of inducing inflammation were more likely to enter the bloodstream in T1D. The overlap of the gut and oral microbiome with the blood microbiome implied potential translocation of bacteria from the gut and oral cavity to the bloodstream. Our study raised the necessity of further mechanistic investigations into the roles of blood microbiome in T1D.收起

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