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作者

Lu Yan, Ledong Sun, Zhiguang Guan, Shanshan Wei, Yanru Wang, Pengfei Li

作者单位

Department of Radiotherapy and Oncology, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong Province. Department of Plastic Surgery and Burn, Taishan People's Hospital, Guangzhou, Guangdong Province. Department of Dermatology, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong Province. Department of Dermatology, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong Province. Electronic address: yanlu710@16 Affiliations com.

刊名

Journal of the American Academy of Dermatology

年份

2020

卷号

Vol.82 No.6

页码

1422-1434

ISSN

1097-6787

关键词

Merkel cell carcinoma Mohs micrographic surgery cancer-specific survival competing risk analysis excision margin overall survival.

摘要

Background: Current guidelines recommend local excision margin with 1 to 2 cm on primary Merkel cell carcinoma sites. Objective: We compared survival outcomes of patients with MCC who were treated with different surgical interventions. Methods: A retrospective analysis of MCC cases in the Surveillance, Epidemiology, and End Results database was performed using the Kaplan-Meier, competing risk, and Cox proportional hazards regression model analyses. Influence of age, T stage, American Joint Com...更多

Background: Current guidelines recommend local excision margin with 1 to 2 cm on primary Merkel cell carcinoma sites. Objective: We compared survival outcomes of patients with MCC who were treated with different surgical interventions. Methods: A retrospective analysis of MCC cases in the Surveillance, Epidemiology, and End Results database was performed using the Kaplan-Meier, competing risk, and Cox proportional hazards regression model analyses. Influence of age, T stage, American Joint Committee on Cancer stage, adjuvant radiotherapy, and other subgroups were also analyzed by pairwise log rank test. Results: Our results indicated a significant association between local destruction method and inferior survival, while an EM >2 cm showed significantly higher overall survival. In addition, the competing risk analysis depicted a similar trend as the Kaplan-Meier analysis, and considerably reduced estimated cumulative incidence. Further subgroup pairwise analysis demonstrated that the EM >2 cm method had better survival in patients who were <60 years of age, having smaller tumor diameters or having undergone adjuvant radiotherapy . In contrast, different EMs did not show any significant association with survival rate in patients ≥75 years of age or stage III tumors. Limitations: This study was not prospectively randomized without relapse data. Conclusions: It is challenging to make optimal EM recommendations, because surgical options may depend on individual case situations. Further prospective randomized studies are warranted.收起

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